Drs. Tian Xiao Hui/Lun
Zheng Guo/Wang Jing Department of Hematology, The First Affiliated
Hospital of Lanzhou Medical College, Drs. Hitoshi Ito/Keishiro Shimura/Wang Jun
Zhi Mie University School of Medicine
Ten cases of acute non-lymphocytic
leukemia (ANLL) were treated with chemotherapy using Agaricus Blazei. The
results showed that Agaricus Blazei could promote the bone marrow hemopoiesis
in vivo, improve bone marrow inhibition after chemotherapy and remarkably
increase the concentration of Hb, the number of Wbc and Plt in peripheral blood
(P<005-0.02). It also enhanced the concentration of lgM (P<0.05), albumin
and A/G ratio and decreased the concentration of globulin in plasma
(P<0.01-0.05). It indicated that Agaricus Blazei could promote liquid immune
function and had some inhibitory effects on leukemia cells in ANLL patients. No
side effects were found in the treatment of Agaricus Blazei. The method is safe
and remains to be further studied and applied.
(Keywords: Agaricus Blazei, Acute
Non-Lymphocytic Leukemia (ANLL), Clinical Treatment)
Agaricus Blazei is a fruit body of
fungi plant. As shown in the experiments and researches by Japanese academics,
its hot water extract (includes water-soluble polysaccharides as a main
component) has effects such as immunological enhancement and tumor growth
inhibition. In animal experiments conducted in China, it was found that the
polysaccharides extracted from Agaricus Blazei (ABPS) promote the proliferation
of CFU-S, CFU-GM, CFU-E and CFU-F of rats. In order to make a progress in its
clinical research and application perspectives, we carried out a clinical
observation of 10 examples of acute nonlymphocytic leukemia patients under
treatment with Agaricus Blazei from July 1992 to May 1994, which we report as
Material and Method
I. Selection of Patients
The subject 20 examples were the
patients with acute nonlymphocytic leukemia who received initial treatment at
the Department of Hematology, The First Affiliated Hospital of Lanzhou Medical
College. All examples comply with the diagnosis standard for acute
nonlymphocytic leukemia established by Tientsin Leukemia Classification
Conference held in September 1986. The patients were randomly divided into
experimental and control groups, each consisting of 10 patients. There is no
obvious difference between the two groups as to their age, the length of period
with disease, condition (symptoms and signs), and chemotherapy that they had
The experimental group consisted of 6
males and 4 females (2 x M2, 2 x M3, 1 x M4
and 5 x M5). Their age ranged 22 - 58 and the average was 34.1.
The control group consisted of 8 males
and 2 females (1 x M1, 1 x M2, 1 x M3, 4 x
M4, 3 x M5). Their age ranged 23 55 and the
average was 36.4.
II. Treatment Method
The experimental group was treat under
chemotherapy of standard induction and remission method including "daunorubicin
+ cytarabine" method with 14 21 days of intermittence period. The
chemotherapy was given 3 times during the period they took medicine made with
Agaricus Blazei. After the first treatment using hot water extract of Agaricus
Blazei (supplied from Iwakin Co., Ltd. Laboratory of Japan), the daily amount
was increased to 20g (twice a day). The patients took the medicine for total 3
The control group patients received
the chemotherapy and conditional support, but did not take the medicine made
from Agaricus Blazei.
III. Monitored Values
1. Clinical Symptoms and Signs:
Mental condition, appetite, nausea,
blood pressure, etc.
2. Laboratory Tests
2.1 Changes in Blood Picture
2.2 Changes in Bone Marrow Picture
2.3 Various items of biochemical blood
tests including plasmatic protein, immunoglobulin, serum iron metabolism, liver
and renal functions.
The number of infected patients and
infected parts of body were monitored.
4. Side Effect:
Patients went through rigid inspection
during and after treatment for any side effects.
5. Statistical Processing:
T inspection processing
was applied to the data of each item.
1. Influence of Agaricus Blazei to the
Blood Picture of Acute Nonlymphocytic Leukemia Patients:
As shown in the experiment result,
peripheral blood hemoglobin, platelets and leukocyte remarkably increase after
treatment with Agaricus Blazei (see Table 1).
2. Influence of Agaricus Blazei to the
Bone Marrow Picture of Acute Nonlymphocytic Leukemia Patients:
Table 1: Influence of Agaricus Blazei
to the Blood Picture of Acute Nonlymphocytic Leukemia Patients (x±S)