Anxiety

Abstract: The Effectiveness of Garum Armoricum (Stabilium)
in Reducing Anxiety in College Students

Dorman T, et al. Journal of Advancement in Medicine, Vol.8(3):193-200, 1995.

Anxiety has been classified as a psychiatric symptom and as such merits treatment. On the other hand it is a common sense observation that mild degrees of anxiety are a normal accompaniment of modern living. This has been reflected in the psychiatric literature, where the frequency of "undiagnosed" anxiety in a primary care setting has been lamented. The management of anxiety with pharmacologic means has been studied extensively and a consensus exists that there is a problem with habituation when using typical drug therapy. Additionally, there is uncertainty regarding how to combine medicinal management for anxiety and depression. There is, therefore, an emerging recognition that further approaches need to be sought.

Two open small studies reported on the benefit of a product prepared from controlled enzymatic autolysis of the viscera of a certain | species of deep sea fish, Garum Armoricum ("GA"), found off the | coast of Brittany, in weakness and fatigue patients with acute anxiety. The current study set out to review the possible benefit of this product in free-floating anxiety of otherwise healthy college students under the stress of final examinations, in a controlled experiment, while maintaining vigilance for possible side effects.

The administration of GA resulted in a statistically significant difference in mean anxiety test scores. Neither difference due to the week of treatment nor the order (GA first vs. placebo first), nor any interaction was statistically significant. Due to an unanticipated lingering anxiolytic effect of GA in the group who received it first (beyond the one week washout allowed in the initial design), their placebo scores were omitted from the placebo analysis. The reduction in anxiety test scores of subjects taking GA was statistically significant during the second and third weeks. This effect continued through the washout week when neither GA nor placebo was administered. Reduction of anxiety test scores for subjects taking placebo were not statistically different from the initial scores.

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