Hydroxyproline is a nonessential amino acid, which means
that it is manufactured from other amino acids in the liver; it does not have
to be obtained directly through the diet.
Hydroxyproline is necessary for the construction of the
body's major structural protein, collagen. Defects in collagen synthesis lead
to easy bruising, internal bleeding, breakdown of connective tissue of the
ligaments and tendons, and increased risk to blood vessel damage. Increased
spill of hydroxyproline in the urine is generally associated with breakdown of
connective tissue due to disease process and may also be a manifestation of
vitamin C deficiency.
Deficiency of hydroxyproline will only occur if there is
a deficiency of vitamin C.
Hydroxyproline has no known therapeutic use.