CoQ10 Curcumin D3 TTopical Cream

CoQ10/Curcumin/D-3 Topical Cream is a multi-ingredient formulation that was inspired by the potential of using these combined substances for both cancer chemoprevention and cancer therapy. The three key bioactive substances present in this product are:

1. Coenzyme Q10 (CoQ10; also known as ubiquinone or ubiquinol) is an organic molecule structurally related to vitamins E and K. It is mainly found in the membranes of the mitochondrion and other organelles (compartments within each cell). The chief functions of CoQ10 are in the generation of cellular energy and acting as an antioxidant.
2. Curcumin is a natural product derived from the turmeric plant (Curcuma longa is a member of the ginger family that is a key ingredient of curry powder). This substance has numerous pharmacological effects; notably, curcumin has anticancer, antiinflammatory, antioxidant and antiamyloid activities.
3. Vitamin D-3 (cholecalciferol) is the specific form of vitamin D made in the human body. It is generated by the action of sunlight (specifically, UVB ultraviolet radiation) on a cholesterol-like molecule in the skin. The main role of vitamin D-3 is in helping bones absorb calcium, thus contributing to normal bone growth and development.

Owing to their antioxidant properties, both CoQ10 and curcumin can help protect cells and tissues from oxidative damage caused by chemical free radicals. Potential health benefits of antioxidants include preventing as well as treating cancer, promoting cardiovascular health, maintaining a healthy immune system, treating a variety of metabolic disorders, alleviating various neurological conditions and protecting against neurodegeneration. While not an antioxidant, vitamin D-3 (as well as its metabolites) has numerous physiological and therapeutic benefits in addition to its prominent role in bone growth, development and maintenance. A particularly noteworthy aspect of CoQ10, curcumin and vitamin D-3 is that all three substances can be applied in topical form, yielding biologically relevant levels in the skin. The physiological and therapeutic effects from the topical application of these agents have been well documented in the scientific literature.

Perhaps the most important area of investigation involving the combined use of CoQ10, curcumin and vitamin D-3 is in cancer prevention and therapy. As noted, CoQ10 can serve as a cancer preventative by conferring protection against cellular damage caused by free radicals. Furthermore, CoQ10 can function as an immune system enhancer. With respect to cancer therapy, perhaps the most prominent benefit of CoQ10 is in helping to prevent anthracycline-induced cardiotoxicity (cardiomyopathy). Anthracycline anticancer agents such as Adriamycin (doxorubicin) can damage heart cells due to the presence of an enzyme found in abundance in the cardiac cell mitochondrial membranes. Oxidative stress resulting from the enzymatic reduction of anthracyclines leads to irreversible mitochondrial damage and eventually to cardiac cell death. CoQ10 can help prevent such damage by protecting the mitochondria of cardiac cells from oxidative effects.

Curcumin has been shown to inhibit chemical carcinogen-induced tumor initiation as well as tumor promotion caused by such agents as the plant-derived phorbol esters. In addition to being used to treat precancerous conditions such as gastrointestinal polyps and myelodysplastic syndrome, curcumin has been tested as a cancer chemotherapeutic agent as either a single agent or in combination with other anticancer drugs. Curcumin has been reported to show effectiveness against such cancers as melanoma, pancreatic cancer, colon cancer, and adenocarcinoma. One mechanism by which curcumin inhibits or kills cancer cells may be through the modulation of various intracellular signal transduction pathways. Other possible mechanisms include the selective induction of apoptosis (programmed cell death) in cancer cells without harming normal cells, and the ability to inhibit nuclear factor-kappaB (NF-kappaB), a transcription factor whose overexpression in many cancer cells is related to tumor progression. Curcumin may also have antimetastatic properties.

Vitamin D supplementation may have a prominent role in cancer prevention as well as in the treatment of numerous forms of cancer, including skin, lung, breast, ovarian, colon and prostate. With respect to the role of vitamin D-3 in cancer prevention, there is epidemiological evidence indicating that supplementation can markedly lower the risk of colon, breast and ovarian cancers. Therapeutically, cancer patients who receive chemotherapeutic or surgical treatment during the summer have increased survival relative to patients treated in the winter, suggesting that Vitamin D may contribute to patient survival. Moreover, some vitamin D-3 metabolites have been used as chemotherapeutic agents, with antiproliferative effects against several types of cancer including breast, colon, and prostate tumors, leukemias and lymphomas. Possible mechanisms by which vitamin D-3 could exert cancer chemopreventive and therapeutic effects include the inhibition of cell proliferation and DNA synthesis, the modulation of signal transduction and/or oncogene expression pathways, induction of cell differentiation, and inhibition of angiogenesis.

There are a number of studies in the scientific literature that have employed CoQ10, curcumin and vitamin D-3 in topical form that extend beyond their use for cancer prevention and therapy. For CoQ10, these include protecting aging skin against oxidative damage by UV in sunlight as well as from chemical free radicals; skin wrinkle reduction (particularly of "crows feet" around the eyes); preventing apoptosis (programmed cell death) of corneal cells exposed to laser irradiation during eye surgery; and the treatment of adult periodontitis. Owing to its antiinflammatory properties, Topically applied curcumin has been used as a psoriasis treatment, as well as to inhibit chemically induced inflammation. Curcumin also has been investigated as a topical wound-healing agent; this may be related both to its antioxidant properties as well as to its antiinflammatory effects. Also, topical curcumin has been reported to be an effective biocide against vaginal infections caused by the type 2 herpes simplex virus. Topical preparations containing vitamin D-3 may have utility in the treatment of inflammatory skin diseases such as psoriasis, with skin healing results comparable or superior to that of conventional therapies (tars, steroids, and dithranol) that have more side effects in addition to being messy to apply.

Supplementation with antioxidants such as CoQ10 and curcumin may have utility in treating autistic patients who often have increased sensitivity to, or decreased protection from, damage caused by chemical free radicals or UV radiation (oxidative stress). As Dr. Woody McGinnis has observed, the use of antioxidants in some of these patients can markedly improve autistic behavior. (The role of oxidative stress in autism, and the use of antioxidants in its treatment, was reviewed by Dr. McGinnis in Alternative Therapies in Health and Medicine, volume 10, pages 22-36, 2004). While there are no overt links between vitamin D deficiency and autism in the scientific literature, there does appear to be a relationship between magnesium deficiency - which can be a factor in autism - and low production of the vitamin D-3 metabolite calcitriol. Vitamin D-3 may also play a role in proper brain development. Because a product such as CoQ10/Curcumin/D-3 Topical Cream is applied to the skin, the common problem of getting autistic children to ingest these substances is avoided.

Ingredients: Deionized Water, Caprylic/Capric Triglyceride, Simugel 600, Coenzyme Q-10, Sepigel 305, Tetrahydrodiferuloylmethane, Lecithin, Alcohol, Phospholipids, Sodium Hydroxymethylglycinate, Disodium EDTA, Potassium Sorbate, Cholecalciferol, Corn Oil, Citric Acid.

2 ounces

For external use only.

Store in a cool, dry place out of direct sunlight.

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