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Prostate Formula Topical Cream
Prostate Formula Cream is a product that was inspired by the potential of utilizing multiple ingredients for both the prevention and treatment of prostate cancer. This product also may be useful for the alleviation of other prostate ailments, such as prostatitis – inflammation of the prostate gland. There are six bioactive substances present in this formulation, three of which are derived from plants: 1) Indole-3-Carbinol (I3C) is a chemical found in cruciferous vegetables such as broccoli, cauliflower and cabbage. In addition to acting as an antioxidant, i3C is known to affect certain enzymatic and biochemical pathways, and to modulate the activity of hormones such as estrogen. This substance has potential in the prevention and/or treatment of cancer and cardiovascular disease. 2) Boswellia Serrata Extract is a natural product preparation derived from the Boswellia tree. The active ingredient, acetyl-keto-beta-boswellic acid (AKBA), has antiinflammatory and antiarthritic activities (as an inhibitor of the enzyme 5-lipoxygenase), as well as potential anticancer effects. 3) Tetrahydrodiferuloylmethane (THFM) is derived from the turmeric plant, Curcuma longa, a member of the ginger family that is a key ingredient of curry powder. This natural product has antioxidant, antiinflammatory and anti-irritant properties and may have other beneficial pharmacological effects. 4) Coenzyme Q10 (CoQ10; also known as ubiquinone or ubiquinol) is an organic molecule structurally related to vitamins E and K. It is found in the membranes of the mitochondrion and other organelles (compartments within each cell). The chief functions of CoQ10 are the generation of cellular energy and antioxidant activity. 5) Tetrahexyldecyl Ascorbate (THDA) is a fat-soluble form of vitamin C that is chemically related to ascorbyl palmitate, but with four times the amount of hydrophobic palmitic acid moieties. The biological properties of Tetrahexyldecyl Ascorbate include antioxidant effects and an ability to stimulate the production of collagen. The components of Prostate Formula Cream may have utility in the treatment of prostatitis, in treating precancerous prostate conditions (e.g., benign prostatic hyperplasia, or BPH) and in the prevention and treatment of prostate cancer. Of the six substances present in Prostate Formula Cream, the one that has generated the most research interest with respect to its use in alleviating prostate ailments is I3C. This has stemmed from epidemiological studies showing that that the increased dietary intake of cruciferous vegetables (which contain I3C as a major chemical constituent) could be related to a decreased risk of developing prostate cancer. The potential utility of I3C in the prevention and treatment of prostate cancer was the subject of a recent review (Sarkar and Li, Journal of Nutrition 134[supplement]:3493S-3498S, 2004). The authors noted that the mechanisms by which I3C might exert its chemopreventive or chemotherapeutic effects include the increased production of enzymes capable of detoxifying and eliminating chemical carcinogens, the regulation of a variety of genes involved in controlling cell proliferation and other cellular functions, and the induction of apoptosis (programmed cell death) in prostate cancer cells (both hormone dependent and hormone-independent cancer cell lines). AKBA, the main active ingredient in Boswellia Serrata Extract, also has been shown to inhibit cancer cells through the induction of apoptosis. Two German studies have identified AKBA as an inducer of apoptosis in hormone-independent PC-3 prostate cancer cells (Syrovets et al., Journal of Biological Chemistry 280:6170-80, 2005; Buchele et al, Plata Medica 72:1285-9, 2006). As the hormone-independent PC-3 cell line is not susceptible to hormonal chemotherapeutic agents, the potential utility of agents such as Boswellia Serrata Extract (AKBA) and I3C in treating prostate cancer becomes obvious, As antioxidants, THFM, CoQ10 and THDA can protect cells and tissues from oxidative damage caused by free radicals. THFM is a purified organic compound (referred to as a curcuminoid) derived from the root of Curcuma longa (the turmeric plant). Like curcumin, its better-known chemical relative, THFM has anticancer, antiinflammatory and antioxidant properties. However, THFM (and related tetrahydrocurcuminoids) appears to have superior antioxidant properties. Most of the research involving the effects of curcuminoids on prostate ailments have centered on their role in the chemoprevention of prostate cancer. The antioxidant CoQ10 serves as a cancer preventative by conferring protection against cellular damage caused by free radicals. CoQ10 supplementation in vitro has been shown to selectively decrease the growth of prostate cancer cell line PC-3 in comparison to that of nonmalignant prostate cells (Quiles et al., Biofactors 18:265-70, 2003). Although not extensively evaluated, CoQ10 can also function as an immune system enhancer. THDA, which is a fat-soluble form of vitamin C (L-ascorbic acid), has an enhanced ability to enter cell membranes and maintain stability within the cells, thus making THDA a superior form of vitamin C for topical use. However, it is the structure of vitamin C itself that permits it to react readily with free radicals to protect cells from oxidative damage. The potential of vitamin C in cancer prevention and treatment has been recognized. Some of the research indicates that vitamin C has selective toxicity to prostate cancer cells (among other cancer cell types). There are also investigations of the role of vitamin C in potentiating antitumor activity in combination with other substances. One such study involves the last of the six ingredients in Prostate Formula Cream to be discussed, the immunomodulatory agent BG. In considering how BG might work with the rest of the bioactive substances present in Prostate Formula Cream, part of the answer comes from a study with BG and vitamin C performed by a New York Medical College research team. They reported that BG could induce apoptosis in human prostate cancer cell lines. Even more interesting, however, is that vitamin C was found to potentiate the antitumor effect of BG. The investigators concluded that BG “...may have great potential as an alternative therapeutic modality for prostate cancer.” (Molecular Urology 4:7-13, 2000). These results suggest that BG itself and, perhaps more importantly, the specific combination of BG and THDA, or BG in combination with other antioxidants may have potential utility in the treatment of prostate cancer. In short, the combination of substances contained in Prostate Formula Cream may represent a novel complementary and alternative medical approach to the treatment of prostate cancer, particularly the form that is resistant to hormonal intervention. Ingredients: Deionized Water, Caprylic/Capric Triglyceride, Simugel 600, Sepigel 305, Coenzyme Q-10, Pumpkin Oil, 30% AKBA (Boswellia Serrata Extract), Tetrahydrodiferuloylmethane, Citric Acid, Sodium Hydroxymethylglycinate, Rosmarinus Officinalis (Rosemary) Leaf Extract, Betaglucan, Tetrahexyldecyl Ascorbate, Lemon Verbana Oil, Bitter Melon Extract, Potassium Sorbate, Tocotrienol, Indole-3-Carbinol, Zinc PCA, Cholecalciferol, Corn Oil 4 ounces Store in a cool, dry place out of direct sunlight. This product is not intended to diagnose, treat, cure or prevent any disease or disorder. The statements contained herein have not been evaluated by the Food and Drug Administration.
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