Herbal Extract Inhibits Angiogenesis
click here for Bindweed product
Bindweed or Convolvulus arvensis is a commonly
found weed and every farmer's nightmare - damaging crops by wrapping itself
around plants such as corn and wheat. Bindweed grows all over the world - from
Europe to China, and from Canada to South America. Farmers actually refer to it
as "the cancer of weeds" - an ironic nickname. This amazing weed has
demonstrated powerful angiogenesis inhibiting properties - testing 100 times
stronger than shark cartilage. With this kind of data, the potential for
patients is enormous: a patient could take just 2 capsules per day of this
extract versus the equivalent of 200 capsules of shark cartilage per day.
100 Times Stronger Than Shark Cartilage
The proteoglycan mixture (PGM) found in bindweed has
tested 100 times more effective than shark cartilage by weight. Using chicken
egg chorioallantoic membrane tests, PGM was found to inhibit angiogenesis from
18% (for doses of 50 mcg per egg) to 73% (for doses of 200 mcg per egg). See
photos and charts. _
The Mechanism Behind The Weed
Researchers at the Center for the Improvement of Human
Functioning in Wichita, Kansas have conducted numerous studies on PGM to
identify the mechanisms behind its anti-neoplastic effects: There are
only a handful of possible mechanisms to look for: immune stimulation,
apoptosis induction; redifferentiation; angiogenesis inhibition; and the direct
killing of tumor cells PGM works as an angiogenesis inhibitor" - Neil Riordan,
Moderate Immune Stimulation
In addition to its angiogenesis inhibiting properties, PGM
is also a moderate immune stimulator. Studies done on PGM's effect on human
lymphocyte growth in vitro have demonstrated an increase in lymphocyte
production from 35 to 46 percent. Physicians working with cancer patients are
reporting positive results consistent with this data. See 'What Doctors Are
Saying after this article.
Numerous animal studies have been performed to determine
the toxicity of bindweed extract. At the equivalent of 1400 grams of PGM for
humans, no toxicity was found in test animals. However it is important to note
that bindweed, before the extraction process, does contain toxic alkaloids.
PGM is a potent angiogenesis inhibitor with mild immune
stimulating properties, such as stimulating lymphocyte production. In animal
studies, faster results occurred when an immune stimulant was added to the PGM.
PGM is currently being studied as an adjunct to chemotherapy and immunotherapy
at the Biocommunications Research Institute in Wichita, Kansas.
The statements made herein have not been evaluated by
the US. Food and Drug Administration This product is not intended to diagnose,
treat, cure, or prevent any disease.
Anti-Angiogenic, Anti-Tumor and
Effects of a Non-Toxic Plant Extract (PGM)
Riordan NH, Meng X, Riordan HD.
Comprehensive Cancer Care 2000, Arlington, Virginia, June, 2000.
Recruitment of new blood vessels plays a crucial role in
tumor survival and growth. Several agents that act as angiogenesis inhibitors
are currently being investigated as anti-tumor agents. Proteoglycan extract
(PGM) was tested for anti-angiogenic, immunostimulatory, and anti-neoplastic
activity. PGM is a non-toxic extract of the ubiquitous plant, Convolvulus
arvensis. In the chicken egg chorioallantoic membrane assay PGM inhibited
new blood vessel growth in a dosedependent manner. Results were 18, 55, and 73%
inhibition at concentrations of 50, 100, and 200 mcg. respectively. PGM
significantly inhibited tumor growth in the mouse fibrosarcoma (S180 Kun
Ming 3-4 weekold mixed male/female, 10 animals per group, 2501000 mcg. daily
doses for 14 days), and mouse Lewis Lung Carcinoma (C57, 6 wk old mixed
male/female, 10 animals per group, 2501000 mcg. Daily doses for 14 days)
models. Inhibition (5477% inhibition by weight compared to controls, up to
96.8% by cellular composition) occurred regardless of route of administration:
intravenous, intraperitoneal, subcutaneous, and oral. PGM induced lymphocyte
growth in a dose dependent manner. The ability of PGM-treated phagocytes to
phagocytose yeast cells was 85% greater than controls. We conclude that PGM is
a potent angiogenesis inhibitor that has immunostimulatory activity in
vitro and anti-tumor activity in vivo and that PGM should be studied further as
an antineoplastic agent.
Every aspect of tumor growth requires vascular growth. In
1971 Folkman hypothesized that controlling angiogenesis could be a feasible
anti-tumor strategy. Recently the description of angiostatin and endostatin has
resulted in increased interest in angiogenesis inhibitors as anti-tumor agents.
Because of an anecdotal report of complete remission in a
case of human ovarian carcinoma after consumption of 'an extract of the
ubiquitous plant Convolvulus arvensis, we tested extract of this plant for
anti-angiogenesis and immune stimulating effects.
Convolvulus arvensis is well known to contain toxic
alkaloids. Therefore, in this study we examined a high molecular weight water
extract of the plant that does not contain appreciable concentrations of
alkaloids, which are depleted in the manufacturing process. The extract is
primarily comprised of proteoglycan molecules and is herein referred to as
Summaries of Animal & Human Studies
See following pages for summaries and results of several
significant animal and human studies conducted by the above researchers
Research has been presented demonstrating that an extract
of the plant Convolvulus arvensis has potent angiogenesis inhibiting and
immune-stimulating qualities. This extract also demonstrated anti-tumor
effects in two mouse tumor models. The exact details regarding the
anti-angiogenesis mechanism of bindweed extract are not completely understood.
This extract should be studied further to elucidate its anti tumor effects and
mechanisms of action. .
Effects of Cell Wall Extracts of Gram Positive
(MPGC) on Human Immunity and Tumor Growth in
Riordan NH, Meng X, Taylor P, Riordan HD. Presented at
Comprehensive Cancer Care 2000, Arlington, Virginia, June, 2000.
Muramyl polysaccharide glycan complex (MPGC) was tested
for its immunostimulatory effects on human mononuclear cells and
lymphocytes and for its anti-tumor effects in the S-180 mouse sarcoma model.
MPGC is a non-toxic purified extract of the bacterial cell walls of gram
positive bacteria. In vitro MPGC (0.1 mg/mL) stimulated the production of
Interleukins 1, 6, and 12, and stimulated human lymphocyte proliferation. A
mixture of cytokines produced by MPGC (0.1 mg/mL) stimulated human monocytes
resulted in the maturation of immature human dendritic cells as evidenced by
flow cytometric quantitation of CD83. Tumors were established in Kun Ming mice
(3-4 weeks old, 19-21 grams each, mixed male/female, 10 animals per group)
after subcutaneous injection of S180 sarcoma cells in the- flank.
Intraperitoneal MPGC (250 mcg/dose, daily for 14 days, first injection 2 days
after tumor establishment) resulted in 75% inhibition of tumor growth. Using
the same model and conditions, intravenous MPGC (250 mcg/dose. daily for 14
days, first injection 2 days after tumor establishment) resulted in 77%
inhibition of tumor growth compared to controls.
We conclude that MPGC has immunostimulatory and anti-tumor
qualities and should be studied further as an immuno-therapeutic agent for
Bacterial and fungal cell wall extracts have been used as
immune stimulants and anti-tumor agents. Examples are Bacillus Calmette-Guerin
(BCG), ~Polysaccharide K, beta 1,3 glucan, the Maruyama vaccine, and extracts
of' Bifidobacterium, L lactis, L. fermentum, L. acidophilus, S. lactis.
Muramic acid is a component of bacterial cell wails with
immunostimulatory qualities that may be partially responsible for the
anti-tumor effects of gram-positive bacterial extracts. Muramyl peptides
(comprised of two muramic acids bound together) sensitize macrophages to
phosphatidylserine and muramic acid, both of which are found preferentially on
tumor cells. Muramyl peptides upregulate monocyte cytokine genes (IL-1 beta,
IL-6, IL-8, IL-12, macrophage chemotatic and activating factor, and tumor
necrosis factor alpha but not lL-2 or IL-10) and activate monocyte-mediated
tumoricidal activity. Muramyl peptides increase the ability of macrophages to
recognize virally infected cells, including cells infected with oncogenic
viruses. Muramyl peptides and muramic acid are not selectively internalized by
monocytes, and therefore have been associated with toxicity.
Monocytes/macrophages have mannose receptors that allow them to readily
internalize polysaccharides that contain mannose.
Muramyl polysaccharide-glucan complex (MPGC), is a
non-toxic bacterial cell well extract of Lactobacillus fermentum that contains
muramic acid moieties attached to variable length mannose rich polysaccharides.
The mannose rich polysaccharides promote internalization of the entire muramic
acid containing complex.
Animal & Human Studies
Summaries and results of several significant animal and
human studies conducted the above researchers can be seen in the following
Research has been presented demonstrating that MPGC has
immune-stimulating and anti-tumor qualities. MPGC should be studied further to
elucidate its anti-tumor effects and mechanisms of action.