It is predicted that FOOD SCIENCE and IMMUNOLOGY will represent the medical treatment in the 21st century

Agaricus Max
Article 2

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Cancer is one of adult's diseases that are most difficult to cure.

In order to treat various cancer, surgical operation, radiotherapy and chemotherapy (administration of anticancer agent) are generally used today. But in any case, their side effect is causing serious damage and suffering to patients. As an alternative to these treatment methods, immunotherapy is now gaining more attention than ever. Immunotherapy substantially reduces the sufferings of side effect and inherent pain of cancer, cures cancer in its last stage and prevents recidivation by promoting the power of immunity that is originally equipped to a human body.

" It is predicted that FOOD SCIENCE and IMMUNOLOGY will represent the medical treatment in the 21st century. "

1. Effect on the circulatory organ system	Pulmonary cancer, severe pneumonia, leukemia, malignant lymphoma, lymphoma caused by Hodgkin's disease, hemiplegia, septicemia, heart diseases, myocardial infarction, arteriosclerosis, angina pectoris, cardiac reinforcement, thrombotic diseases, vasoconstrictive diseases, hypertension/hypotension, restoration, stamina supply, etc.
2. Effect on the digestive system	Ascitic cancer, colic cancer, rectal cancer, sigmoid cancer, intestinal cancer, pancreatic cancer, splenic cancer, Liver Cancer, hepatocarcinoma, hepatocirrhosis, hepatitis A/B/C, hepatomegaly, gastric cancer, gastric ulcer, chronic gastritis, gastroptosis, duodenal ulcer, viral enteritis, renal cancer, nephritis, renal failure, polyposis, pimples, chronic stomatitis, pyorrhea, constipation, lost appetite, hemorrhoids, etc.
3. Effect on the endocrine system	Diabetes mellitus, hyperlipidemia (hyper cholesterol), allergy, edema, hepatopathy, etc.
4.Effect on the cranial nerve metabolism system	Multiple rheumarthritis, rheumatoid arthritis, autonomic imbalance, neurosis, Japanese encephalitis, etc.
5. Effect on the respiratory system	Chronic bronchitis, asthma, etc.
6. Effect on the genital system	Breast cancer, ovary cancer, mammitis, gynopathy, monstrous irregularity, climacteric disorder, etc.
7. Effects on the urinary system	Cystitis, prostatomegaly, nephrosis, etc.
8. Effect to the cutaneous system	Athlete's foot, eczema, atopic dermatitis, dermatomyositis, ciliary skin tumor, etc.
9. Other effects	Pollinosis, chronic rhinitis, empyema, Basedow’s disease, collagen disease, roseolar arthritis, influenza, asthenia, lumbago, frozen shoulder, stiff shoulder, ophthalmopathy, blood purifyication, cold constitution, lost energy, hangover, acquired immunity deficiency syndrome (AIDS), etc.

It is predicted that Agaricus Blazei Murrill has effects to improve such symptoms as listed above

These effects are said to be the result of the activation of immunity function caused by b-glucan, a-glucan, b-galactoglucan, Ribonucleotide-protein complex (RNA), b-(1-6)-D-glucan protein complex, Xyloglucan, etc. that are abundantly included in Agaricus Blazei Murrill. In the experiment made by a research group led by Professors Hitoshi Ito (M.D./Pharmacologist) and Keishiro Shimura (Pharmacologist) at Mie (National) University of Japan, Agaricus Blazei Murrill was administered to mice with implanted cancer. Their complete recovery rate turned out to be 90.4% and arrest rate was 99.4%. The results were reported at general meetings at Japanese mycological, cancer, and pharmacological academies, etc.

Agaricus Max ™ is manufactured using a special technique from genuine Agaricus Blazei Murrill with confirmed efficacy through clinical tests at a national university hospital, which is specially grown in the region called Piedate in Brazil. Be sure to look for Agaricus Max ™, since there are other poor quality products on the market, carrying the name of Agaricus but no medical/scientific assurance of efficacy.

A U.S. Patent as an oral remedy for AIDS has been obtained. Patent Number : 6120772

Registration filing is also being made in Canada, Mexico and 15 European countries.
(The Brazilian countory Ministry of Health and Welfare registration number : MS 001-002-004. 358-98)

Professor Inosuke Iwaide at Tokyo (National) University of Japan succeeded in artificial cultivation of Agaricus Blazei Murrill for the first time in the world. Its effect on various diseases was reported to general meetings of scientific academies by Professors Hitoshi Ito (M.D./Pharmacologist) and Keishiro Shimura (Pharmacologist) at Mie (National) University Japan. Agaricus Max ™ is made under supervision of these professors at Iwaide Fungology Research Corporation and distributed worldwide by U.S.-based MAX LIVE CORP.

Healed Cases

(1) Mr. Fujimoto’s case (overcame cancer with only 5% of possibility of healing)

Mr. Fujimoto’s testicular tumor was found in September 1988 and he had an operation immediately. However, the cancer had already metastasized to his lungs and peritoneum through his lymphoglandula. He was told that he could live for only 3 – 6 more months. Mr. Fujimori, who was diagnosed to have a cancer of 95% fatality rate, started to take Agaricus Blazei Murrill because one of his neighbors recommended it through his experience of overcoming a vesical cancer of the last stage. He was under intravenous feeding of anticancer when he started to take Agaricus Blazei Murrill. His doctor anticipated side effects, which turned out to be almost non-existent, and Mr. Fujimoto showed a recovery by walking around in the hospital. His cancer kept hanging in the balance, but one month later, the X-ray shadow in his lungs disappeared and many cancer cells in his peritoneum was eliminated. His blood test result demonstrated that he was a normal person. His doctor stopped further scheduled operation and it was confirmed through the last abdominal operation that all his cancer cells were gone. Mr. Fujimoto is alive, and back to his job now.

(2) Mr. Miyoshi’s case (fine and sound 12 years after a big surgery)

Mr. Miyoshi was found to have stomach cancer and his remaining life was estimated as 3 months. The result of diagnosis was desperate even if he would go through a surgery, but Mr. Miyoshi insisted to have the operation. A big abdominal operation including extraction of the wholly undermined stomach and resection of esophageal, spleen and pancreas was performed. The operation was a success, but critical condition persisted due to his exhaustion. Mr. Miyoshi started to take Agaricus Blazei Murill because his family recommended it. After a certain period of progress and retrogress, he has survived well beyond the estimated 3 months – and now it is 12 years after the operation. Fine and sound in his 70’s, he is vigorously working every day at a nearby farmland cultivating vegetables without using pesticides. No one would believe that he was expected to die 12 years ago.

(3) Ms. Kayoko T’s statement (overcame rheumatism with no hope of recovery)

Deformation of my fingers started when I was 32. My wrists got swollen and it was hard to bend them. Though I received continuous treatment at university and private hospitals, the situation only got worse. One day I asked my doctor if any surgery is possible for my disease. The doctor said no and passed me a large paper bag full of medicines as usual. So I had to continue taking the medicines, suffering from its side effects when a friend of mine recommended me to take Agaricus Blazei Murill. After a discussion about it with my husband, I started to take it, though a little dubiously. A month later, I felt less pain and fatigue. In two months, my swelling began to decrease in size. Once I could not even hold a glass, but I could hold a needle then. When I visited the hospital for checkup 3 months after I started to take Agaricus Blazei Murill, the doctor said that my rheumatic symptoms are gone. I am so happy now, since I recovered my health again with no side effects, thanks to Agaricus Blazei Murill.

(4) Ms. Kazuko O’s statement (overcame diabetes mellitus with decrease of sight)

One day I felt fatigue, lack of concentration and decreased energy. I consulted a doctor and learned that I had diabetes. The doctor gave me medicines and dietotheraphy instructions. Tasteless meals made me feel gloomy. What was worse, my diabetes was complicated by a second disease – I started to have a cerebral hemorrhage in the eyes – though I followed every instructions from my doctor.. The white of my right eye turned black and my left eye always carried some black spots. The doctor recommended an immediate operation which I accepted. After the operation, my eyes recovered whiteness. But I lost substantial sight, which I could not recover by wearing glasses. On the other hand, my blood sugar value did not drop while I lost my body weight. At this period my concerns reached the peak, worrying about possibility of side diseases and dystrophia even if I would follow all the instructions from my doctor. So I jumped when the idea of trying Agaricus Blazei Murrill was suggested by a friend of mine. During one month of trial of the recipe, my sight was regained without glasses, my blood sugar value fell down and the lost body weight was recovered. Now I am spending pleasant days again.

(5) Research on the treatment of acquired immune deficiency syndrome (AIDS)

The clinical research was performed in Thailand, where reportedly there are more AIDS patients than in any other Asian country. Agaricus Max ™ was administered to 50 AIDS patients for 3 months and the result was monitored.

Hospitalized patients had the lymphoglandula around their eyes, neck and vesica hypertrophied to the size of a clenched fist and their symptoms demonstrated that they were in the last stage of AIDS. One month after the administration of Agaricus Max was stated, its effect on their immunity revival was apparent. After three months of administration, the lymphoglandula of all 50 patients regained the original size. The patients were no longer in the last stage AIDS and released from the hospital, but they still have to visit the hospital since they have not been completely cured. Their clinical conditions are being studied further.

(6) Hypercholesterolemia was improved.
(7) Serious pollinosis was improved within one month of administration.
(8) Serious empyema with completely lost sense of smell was improved.
(9) Never-ceasing attack of asthma with hypotension was overcome.
(10) Acute pain in the lower half of body and cystitis were overcome.
(11) Hypertension that has long been distressing finally disappeared.
(12) Basedow's disease was improved in 4^5 weeks after start of the recipe.
(13) Very severe pain unique to cancer patients was eased.
(14) There are too many other examples to be listed here.

Clinical Test Examples

1. Observation of Agaricus Blazei Murrill's therapeutic effect against digestive tract tumor

20 patients with malignant digestive tract tumor were divided into experimental group that received administration of Agaricus Blazei Murrill and control group who did not receive it. These patients were observed for three months of treatment and all scheduled perspectives were recorded before and after administration.

Since it had been proven that Agaricus Blazei Murrill would not cause any side effects, all patients were also treated with anti-cancer agent, etc. during the same period.

Comparison between Basic Conditions of Patients in the Two Groups

Group	# of Patients		Age	Cancer Location
Group	Male	Female		Esophageal	Stomach	Colon
Experimental Group	8	2	40 – 77	3	5	2
Control Group	9	1	32 - 67	4	5	1

Result

(1) Symptoms and Signs: The symptoms such as fatigue, anorexia, nausea and vomitus of control group patients continued, and in some cases deteriorated. The symptoms of experimental group patients, including mental condition, anorexia and nausea were noticeably improved. No dysphoria or side effects caused by taking the recipe was observed.

(2) Changes in Blood Picture: Experimental group patients' blood picture was improved. On the other hand, the blood picture of control group patients obviously deteriorated. Especially the depression of platelets was remarkable. Therefore, it is considered that Agaricus Blazei improves the peripheral blood picture.

(3) Conclusion: The inspection results of the kidney function, liver function and electrocardiogram of experimental group patients are all within normal ranges. Radiotherapy and chemotherapy, as well as malignant tumor itself, weakens the immunity function inside the human body. In addition to its hematopoietic promotion, Agaricus Blazei is also considered to promote the restoration of retarded myelopoiesis after radiotherapy and chemotherapy, while promoting the immunity function and inhibiting the tumor growth.

2. Observation of Agaricus Blazei Murrill's therapeutic effect on liver function of chronic hepatitis patients

20 patients with chronic and active hepatitis B were divided into experimental group that received administration of Agaricus Blazei Murrill and control group who did not receive it. These patients were observed for three months of treatment and all scheduled perspectives were recorded before and after administration. All patients were presenting the general clinical expression of chronic hepatitis caused by virus. Since it had been proven that Agaricus Blazei Murrill would not cause any side effects, all patients were also treated with appropriate medicines during the same period.

Comparison between Basic Conditions of Patients in the Two Groups

Group	# of Patients		Age	Diagnosis
Group	Male	Female		11 patients with complexion of liver disease, 7 with spider-like nevus and liver palms, 6 with jaundice, 6 with swollen liver and 5 with positive ascites.
Experimental Group	9	1	27 – 55
Control Group	8	2	21 - 57

Result

(1) The symptoms of most of the experimental group patients were improved. For example, symptoms such as abdominal distension, fatigue and hepatodynia either disappeared or improved. Signs were also improved to some degree. The number of patients with retraction of the liver and spleen decreased to 5 and 3 respectively, and 2 patients with ascites retraction was improved. It was obvious that the improvement in the clinical symptoms of the experimental group exceeded that of the control group.

(2) After 3-month of treatment using Agaricus Blazei, the liver function was obviously improved, and there was a remarkable change in values including ALT, AST, bilirubin. It is obvious that Agaricus Blazei has a therapeutic effect against enzyme depression and jaundice.

(3) Agaricus Blazei influences to all correlative perspectives of the liver function of chronic hepatopath. Serum connective cholic acid, serum ferritin, g-globulin, coagulation time after the treatment showed remarkable depression. It is conceived that Agaricus Blazei has various therapeutic effects to hepatopaths and presents a comprehensive control in the positive direction.

(4) The treatment was especially effective to 2 patients and effective to 8 patients of total 10 patients of experimental group. Through this experiment, it was found out that Agaricus Blazei Murrill is effective in promoting the recovery of hepatocytes of chronic hepatitis patients as well as in its immunological enhancement and anticancer activity.

3. Clinical observation of Agaricus Blazei Murrill's therapeutic effect against acute non-lymphocytic leukemia

20 patients with acute non-lymphocytic leukemia were divided into experimental group that received administration of Agaricus Blazei Murrill and control group who did not receive it. These patients were observed for three months of treatment and all scheduled perspectives were recorded before and after administration. The patients were with acute non-lymphocytic leukemia and were receiving treatment at the Department of Hematology, The First Affiliated Hospital of Medical College. Chemotherapy was given 3 times during the period they took medicine made with Agaricus Blazei Murrill, with 21 days of intermittence period.

Comparison between Basic Conditions of Patients in the Two Groups

Group	# of Patients		Age	Diagnosis
Group	Male	Female		M₁	M₂	M₃	M₄	M₅
Experimental Group	6	4	22 – 58	0	2	2	1	5
Control Group	8	2	23 - 55	1	1	1	4	3

Result

(1) Because of the influence of Agaricus Blazei Murrill to the blood picture, peripheral blood hemoglobin, platelets and leukocyte remarkably increased. Among the patients in experimental group, 8 patients reached complete remission (CR) and 2 patients remained with no remission (NR). The bone marrow pressure time after the chemotherapy was short. Bone marrow proliferation ratio between red, granule and large nucleus cells recovered the normal level after the chemotherapy.

(2) Mental condition and appetite of the experimental group patients were remarkably improved. Obvious recovery in symptoms including fatigue, dizziness, nausea and vomitus of 8 patients was reported. The experimental group suffered fewer side effects compared to the control group.

(3) Compared to the control group, far less number of experimental group patients were found to have pulmonary, pharyngolaryngeal, or intestinal infection and the level of infection was lower. No adverse effect was observed during the administration period.

The above result was reported to meetings of Japanese mycological, cancer, pharmacological and control animal academies and international fungology symposium symposium, etc. from a study group led by professor Hitoshi Ito (M.D./ Pharmacologist) of Mie (National) University of Japan.