Hypercoagulation & Heparin A
Second Look
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2
Patricia Kane, Ph.D.
It has
been suggested that the use of heparin will address hypercoagulation. Recent
data from JAMA1 indicates that the use of low dose heparin may transform a
‘benign fungal infection into a toxic shock-like reaction’.
This
research was presented at the 39th annual meeting of the Infectious
Diseases Society of America in 2001 by Margaret K. Hostetter, M.D.2, 3 of Yale
University School of Medicine. Hostetter and colleagues found that Candida
albicans can attach to host cells and form invasive hyphae which ultimately may
create virulence of C. albicans.
Low dose
heparin utilized in hospitalized patients through the practice of heparin in
intravascular catheters may transform the yeast into a life threatening
pathogen1. The use of heparin raises the cytokines TNF alpha1 and IL-6 1 in
addition to Phospholipase A 2 .4, 5, 6. Biotoxins which form neurotoxins, may
create a state of hypercoagulation from the rise in TNF alpha.
Consequently, the use of heparin may exacerbate the neurotoxic
condition and hypercoagulation.
References:
1.
Stephenson J. Can a Common Medical Practice Transform Candida Infections from
Benign to Deadly? JAMA286:20: Nov 28, 2001.
2.
Hostetter MK. Fungal infections in the neonatal intensive care. Semin Pediatr
Infect Dis 12(4); 296-300, Oct 2001.
3. San-Blas G, et al.
Fungal morphogenesis and virulence. Med Mycol 38 Suppl 1:79-86, 2000.
4. Mudher AK, et al.
Heparin injection into the adult rat hippocampus induces seizures in the
absence of macroscopic abnormalities. Neuroscience 89:2:329-333, Mar 1, 1999.
5. Kern H, et al.
Heparin induces release of phospholipase A2 into the splanchnic circulation.
Anesth Analg 91:3:528-532: Sept 2000.
6. Farooqui AA, et al.
Inhibitors of intracellular phospholipase A2 activity: Their neurochemical
effects and therapeutic importance of neurological disorders. Brain Res Bull
49:3:139-153, June 1999.
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